The Week’s 10 Biggest Funding Rounds: Cybersecurity, AI And Health Take The Lead

Follow the largest startup investments of 2026 by exploring our curated overview of $100 million-plus venture capital transactions involving U.S. enterprises over at The Crunchbase Megadeals Board.

This weekly installment highlights the top 10 announced U.S. funding rounds. Review the previous week’s major financing roundup here.

This week brought a robust wave of substantial startup capital infusions, spearheaded by a pair of $400 million investments directed at cybersecurity unicorns Island and Cyera. Additional massive financings spanned several high-demand sectors, such as foundational AI, drug discovery, neurotech, and atmospheric cloud seeding.

1. Island, $400M, cybersecurity: Island, a creator of tools designed for secure enterprise digital workflows, secured $400 million through a Series F funding round. Spearheaded by Evolution Equity Partners, the financing values the Dallas-based enterprise at $6.4 billion—more than double its valuation from 2024.

2. Cyera, $400M, cybersecurity: Cyera, a developer of enterprise data security solutions that manage both human users and AI agents, gathered $400 million in a Series G extension round led by Evolution Equity Partners with backing from Goldman Sachs Growth Equity. This transaction pushes the total capital raised by the New York-based business to $2.7 billion, per Crunchbase data.

3. Snorkel AI, $350M, foundational AI: San Francisco-based Snorkel AI, a supplier of resources allowing frontier labs and AI engineering teams to build specialized training environments and data, closed a $350 million Series E round. Led jointly by Insight Partners and S32, the deal values the 7-year-old firm at $3.2 billion, alongside topping $375 million in annual recurring revenue.

4. Enveda, $311M, biotech: Enveda, an artificial intelligence-driven drug discovery enterprise, brought in $311 million for its Series E financing. Led by Catalio Capital Management alongside numerous new and returning backers, the Boulder, Colorado-based company has now raised over $845 million since its inception.

5. Precision Neuroscience, $250M, neurotech: New York-based Precision Neuroscience, an innovator working on brain-computer interface equipment, collected $250 million via Series D financing with Pershing Square and the Ackman Oxman Institute serving as lead investors.

6. Hubble Network, $200M, wireless communications: Hubble Network, which manages a satellite constellation designed to widen connectivity for Bluetooth appliances, obtained $200 million in Series C financing. Smith Point Capital headed the transaction, placing a $1.6 billion valuation on the Seattle-based organization.

7. Rightway, $155M, pharmacy benefits: New York-headquartered Rightway, a provider specializing in care navigation and pharmacy benefits, secured $155 million in a Series E round spearheaded by Francisco Partners. The startup intends to leverage the funds partly to scale its AI capabilities.

8. (tied) Rainmaker, $100M, cloud seeding: El Segundo, California-based Rainmaker, an enterprise dedicated to atmospheric research and generating fresh water via cloud seeding, picked up $100 million in Series B funding. Participants in the round include Noa, Upfront Ventures, DCVC, Lowercarbon Capital, and Dream Ventures.

9. (tied) Numeral, $100M, tax compliance: San Francisco-based Numeral, an artificial intelligence-driven sales tax compliance platform, finalized a $100 million Series C investment led by Insight Partners.

10. (tied) Micro1, $100M, AI data: San Francisco-based Micro1, a creator of AI training data utilized by major labs, has reportedly secured a fresh investment topping $100 million at a $4 billion valuation, according to a Forbes article referencing sources close to the agreement.

Methodology

We evaluated the largest announced rounds logged in the Crunchbase database by U.S.-registered companies between Sept. 19-25, 2026. While the vast majority of completed announcements are indexed instantly, minor reporting delays can occasionally occur for rounds disclosed late in the week.

Illustration: Dom Guzman