The Week’s 10 Biggest Funding Rounds: Cybersecurity, AI And Health Take The Lead

Keep track of the largest startup funding deals in 2026 featuring $100 million-plus venture investments in U.S.-based companies by visiting The Crunchbase Megadeals Board.

This weekly feature breaks down the Top 10 announced funding rounds in the U.S. for the week. You can review last week’s biggest funding deal roundup here.

This week brought an abundance of major startup capital rounds, highlighted by a pair of $400 million financings for cybersecurity unicorns Island and Cyera. The rest of the week featured large investments in high-demand industries such as foundational AI, drug discovery, neurotech, and even cloud-based rainmaking.

1. Island, $400M, cybersecurity: Island, a creator of secure enterprise digital operation tools, secured $400 million in a Series F financing round. Evolution Equity Partners spearheaded the investment, valuing the Dallas-based business at $6.4 billion—more than double its 2024 valuation.

2. Cyera, $400M, cybersecurity: Cyera, a developer of enterprise data security tools designed to govern both humans and artificial intelligence agents, secured $400 million through a Series G extension round. Evolution Equity Partners led the financing with backing from Goldman Sachs Growth Equity, pushing New York-based Cyera’s total funding to $2.7 billion according to Crunchbase data.

3. Snorkel AI, $350M, foundational AI: San Francisco-based Snorkel AI, which supplies tools helping frontier labs and AI teams build specialized training data and environments, closed a $350 million Series E round. Insight Partners and S32 led the financing, valuing the 7-year-old enterprise at $3.2 billion while driving its annual recurring revenue past $375 million.

4. Enveda, $311M, biotech: Enveda, an artificial intelligence-driven drug discovery company, raised $311 million in Series E capital. Catalio Capital Management led the round alongside a broad group of new and returning investors, lifting the Boulder, Colorado-based firm’s total capital raised since inception above $845 million.

5. Precision Neuroscience, $250M, neurotech: New York-based Precision Neuroscience, a venture developing brain-computer interface technology, obtained $250 million in Series D funding. Pershing Square and the Ackman Oxman Institute served as the lead investors.

6. Hubble Network, $200M, wireless communications: Hubble Network, an operator of a satellite constellation extending connectivity to Bluetooth items, brought in $200 million via Series C funding. Smith Point Capital managed the investment, giving the Seattle-based company a valuation of $1.6 billion.

7. Rightway, $155M, pharmacy benefits: New York-based Rightway, an enterprise offering pharmacy benefits and care navigation solutions, secured $155 million in Series E financing steered by Francisco Partners. The startup plans to allocate a portion of the capital toward growing its AI capabilities.

8. (tied) Rainmaker, $100M, cloud seeding: El Segundo, California-based Rainmaker, an enterprise specializing in atmospheric research and generating new freshwater through cloud seeding, brought in $100 million in Series B funding. Participants in the round included Noa, Upfront Ventures, DCVC, Lowercarbon Capital, and Dream Ventures.

8. (tied) Numeral, $100M, tax compliance: San Francisco-based Numeral, an artificial intelligence-driven platform for sales tax compliance, finalized a $100 million Series C round led by Insight Partners.

8. (tied) Micro1, $100M, AI data: San Francisco-based Micro1, a supplier of AI training data utilized by leading AI labs, has reportedly collected a new funding injection exceeding $100 million at a $4 billion valuation, according to a Forbes report referencing sources close to the transaction.

Methodology

We monitored the largest publicly announced rounds within the Crunchbase database secured by U.S.-based companies covering the timeframe of Sept. 19-25, 2026. While the vast majority of announced rounds are cataloged, a brief delay may occur due to transactions disclosed late in the week.

?Frequently Asked Questions

01What constitutes a megadeal in startup funding?

A megadeal typically refers to a venture capital investment round of $100 million or more raised by a startup company.

02Which sectors dominated this week’s funding rounds?

This week’s top rounds were heavily led by cybersecurity, foundational AI, and health-related sectors such as biotech and neurotech.

03Where does the funding data originate?

The data is tracked from the Crunchbase database, focusing specifically on announced rounds for U.S.-based companies during the designated weekly period.

Illustration: Dom Guzman